The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2011
Filed:
Oct. 26, 2005
Kiyotaka Nakano, Shizuoka, JP;
Izumi Sugo, Shizuoka, JP;
Masamichi Sugimoto, Kanagawa, JP;
Takahiro Ishiguro, Kanagawa, JP;
Megumi Tanaka, Shizuoka, JP;
Shigeyuki Iijima, Shizuoka, JP;
Kiyotaka Nakano, Shizuoka, JP;
Izumi Sugo, Shizuoka, JP;
Masamichi Sugimoto, Kanagawa, JP;
Takahiro Ishiguro, Kanagawa, JP;
Megumi Tanaka, Shizuoka, JP;
Shigeyuki Iijima, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
An anti-glypican 3 antibody with modified sugar chains, more specifically, an anti-glypican 3 antibody lacking fucose is provided. The anti-glypican 3 antibody with modified sugar chains of the present invention may be produced by a process comprising introducing a nucleic acid encoding an anti-glypican 3 antibody into host cells with reduced fucose addition capability, such as YB2/0 cells and cells lacking a fucose transporter. The anti-glypican 3 antibody with modified sugar chains of the present invention has a high level of cytotoxic activity and therefore is useful as a cell growth inhibitor such as an anticancer agent.