The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 2010
Filed:
Sep. 16, 2009
Luca Gobbi, Muttenz, CH;
Georg Jaeschke, Basel, CH;
Rosa Maria Rodriguez Sarmiento, Basel, CH;
Lucinda Steward, Basel, CH;
Luca Gobbi, Muttenz, CH;
Georg Jaeschke, Basel, CH;
Rosa Maria Rodriguez Sarmiento, Basel, CH;
Lucinda Steward, Basel, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention provides compounds of the general formula (I) wherein X, n and Rare as described herein, as well as pharmaceutically acceptable salts and esters thereof, methods for their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are dual modulators of the serotonin 5-HTand dopamine Dreceptors, useful in the treatment and/or the prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.