The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2010
Filed:
Mar. 01, 2007
Tatsuya Niimi, Tokyo, JP;
Akio Kamikawa, Tokyo, JP;
Yasushi Amano, Tokyo, JP;
Tomohiko Yamaguchi, Tokyo, JP;
Kenichi Suzumura, Tokyo, JP;
Kentaro Enjo, Tokyo, JP;
Takashi Furutani, Tokyo, JP;
Akio Kakefuda, Tokyo, JP;
Yutaka Kondoh, Tokyo, JP;
Masaaki Hirano, Tokyo, JP;
Tatsuya Niimi, Tokyo, JP;
Akio Kamikawa, Tokyo, JP;
Yasushi Amano, Tokyo, JP;
Tomohiko Yamaguchi, Tokyo, JP;
Kenichi Suzumura, Tokyo, JP;
Kentaro Enjo, Tokyo, JP;
Takashi Furutani, Tokyo, JP;
Akio Kakefuda, Tokyo, JP;
Yutaka Kondoh, Tokyo, JP;
Masaaki Hirano, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.