The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 2010
Filed:
Dec. 27, 2005
Martin A. Billeter, Zurich, CH;
Pius Spielhofer, Buron, CH;
Karin Kälin, Gif-su-Yvette, FR;
Frank Radecke, Ulm, DE;
Henriette Schneider, Zurich, CH;
Martin A. Billeter, Zurich, CH;
Pius Spielhofer, Buron, CH;
Karin Kälin, Gif-su-Yvette, FR;
Frank Radecke, Ulm, DE;
Henriette Schneider, Zurich, CH;
Crucell Switzerland AG, Bern, CH;
Abstract
The present invention relates, in general, to a methodology or the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.