The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2010
Filed:
May. 31, 2005
Keisuke Yoshino, Ann Arbor, MI (US);
Shigenori Nozawa, Kanagawa, JP;
Masashi Isozaki, Kanagawa, JP;
Seigo Sawada, Tokyo, JP;
Ikuo Kato, Tokyo, JP;
Takeshi Matsuzaki, Tokyo, JP;
Keisuke Yoshino, Ann Arbor, MI (US);
Shigenori Nozawa, Kanagawa, JP;
Masashi Isozaki, Kanagawa, JP;
Seigo Sawada, Tokyo, JP;
Ikuo Kato, Tokyo, JP;
Takeshi Matsuzaki, Tokyo, JP;
Terumo Kabushiki Kaisha, Tokyo, JP;
Kabushiki Kaisha Yakult Honsha, Tokyo, JP;
Abstract
Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.