The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2010
Filed:
Oct. 08, 2009
S. Christopher Davis, San Francisco, CA (US);
Gjalt W. Huisman, San Carlos, CA (US);
Stephane J. Jenne, Foster City, CA (US);
Anke Krebber, Palo Alto, CA (US);
Lisa Marie Newman, San Jose, CA (US);
S. Christopher Davis, San Francisco, CA (US);
Gjalt W. Huisman, San Carlos, CA (US);
Stephane J. Jenne, Foster City, CA (US);
Anke Krebber, Palo Alto, CA (US);
Lisa Marie Newman, San Jose, CA (US);
Codexis, Inc., Redwood City, CA (US);
Abstract
The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.