The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2010
Filed:
May. 19, 2003
Ellen S. Vitetta, Dallas, TX (US);
Victor F. Ghetie, Dallas, TX (US);
Joan Elizabeth Smallshaw, Dallas, TX (US);
Roxana G. Baluna, Richardson, TX (US);
Ellen S. Vitetta, Dallas, TX (US);
Victor F. Ghetie, Dallas, TX (US);
Joan Elizabeth Smallshaw, Dallas, TX (US);
Roxana G. Baluna, Richardson, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.