The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2010
Filed:
Nov. 20, 2002
Jan H. J. Hoeijmakers, Zevenhuizen, NL;
Steven Bergink, Rotterdam, NL;
Gijsbertus Theodoras Johannes Van Der Horst, Rhoon, NL;
Wim Vermeulen, Zwijndrecht, NL;
Mei Yin NG, Philadelphia, PA (US);
Jan H. J. Hoeijmakers, Zevenhuizen, NL;
Steven Bergink, Rotterdam, NL;
Gijsbertus Theodoras Johannes van der Horst, Rhoon, NL;
Wim Vermeulen, Zwijndrecht, NL;
Mei Yin Ng, Philadelphia, PA (US);
Erasmus Universiteit Rotterdam, Rotterdan, NL;
Abstract
A method is provided for determining whether an agent is capable of inducing a DNA lesion in a eukaryotic cell, including exposing the eukaryotic cell to the agent and determining whether an HR23 protein-binding molecule accumulates in the cell, where the HR23 protein-binding molecule is preferably xeroderma pigmentosum group C (XPC), 3-methyladenine DNA glycosylase (MAG), CREB, p53, or a functional part, derivative, and/or analogue thereof. Preferably the cell overexpresses HR23A and/or HR23B protein. A rapid and sensitive test is provided with significant advantages over the Ames test. A method is provided for determining whether an agent is capable of inhibiting a cellular process, the process resulting in accumulation of HR23 protein-binding molecule within a cell. A method for determining whether a cell has an impaired DNA repair system is provided. An impaired DNA repair system is indicative for diseases such as xeroderma pigmentosum, cockayne syndrome, and/or trichothiodystrophy.