The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2010
Filed:
Aug. 11, 2005
Mark A. Ashwell, Carlisle, MA (US);
Chiang J. LI, West Roxbury, MA (US);
Manish Tandon, Framingham, MA (US);
Yanbin Liu, Acton, MA (US);
Jean-marc Lapierre, Pelham, NH (US);
Zhiwei Jiang, Stow, MA (US);
Mark A. Ashwell, Carlisle, MA (US);
Chiang J. Li, West Roxbury, MA (US);
Manish Tandon, Framingham, MA (US);
Yanbin Liu, Acton, MA (US);
Jean-Marc LaPierre, Pelham, NH (US);
Zhiwei Jiang, Stow, MA (US);
ArQule, Inc., Woburn, MA (US);
Abstract
The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified β-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as β-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.