The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Oct. 15, 2008
Antibodies and methods for generating genetically altered antibodies with enhanced effector function
Luigi Grasso, Bryn Mawr, PA (US);
Nicholas C. Nicolaides, Garnett Valley, PA (US);
Howard Sands, Wilmington, DE (US);
Philip M. Sass, Audubon, PA (US);
Luigi Grasso, Bryn Mawr, PA (US);
Nicholas C. Nicolaides, Garnett Valley, PA (US);
Howard Sands, Wilmington, DE (US);
Philip M. Sass, Audubon, PA (US);
Morphotek, Inc., Exton, PA (US);
Abstract
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulin genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the effector function of monoclonal antibodies and monoclonal antibodies with increased effector function.