The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2010
Filed:
Mar. 17, 1998
Jian NI, Rockville, MD (US);
Reiner L. Gentz, Silver Spring, MD (US);
Guo-liang Yu, Darnestown, MD (US);
Jeffrey Y. Su, Gaithersburg, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Jian Ni, Rockville, MD (US);
Reiner L. Gentz, Silver Spring, MD (US);
Guo-Liang Yu, Darnestown, MD (US);
Jeffrey Y. Su, Gaithersburg, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.