The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 21, 2010
Filed:
Apr. 03, 2003
Bryan W. Paeper, Seattle, WA (US);
Sean Proll, Seattle, WA (US);
Patrick R. Charmley, Seattle, WA (US);
Mary E. Brunkow, Seattle, WA (US);
Andreas Gerardus Uitterlinden, Poortugaal, NL;
Bryan W. Paeper, Seattle, WA (US);
Sean Proll, Seattle, WA (US);
Patrick R. Charmley, Seattle, WA (US);
Mary E. Brunkow, Seattle, WA (US);
Andreas Gerardus Uitterlinden, Poortugaal, NL;
Celltech R & D, Inc., Bothell, WA (US);
Abstract
Compositions and methods are provided for determining in a subject a risk for having, or presence of, altered bone mineral density such as osteoporosis or osteopenia or other conditions characterized by decreased or increased bone density. Specifically, the invention relates to determination of a sclerostin gene region nucleotide polymorphism (SRP) in DNA of the sclerostin gene region of human chromosome 17. In certain embodiments, SRPs that indicate an increased risk for altered bone mineral density occur as gender-associated polymorphisms. Isolated polynucleotides comprising representative SRPs are also provided.