The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2010
Filed:
Jan. 05, 2006
Joel M. Van Gelder, Jerusalem, IL;
Joseph Y. Klein, Haifa, IL;
Yochai Basel, Rechovot, IL;
Anat Reizelman, Rechovot, IL;
Susanna Tchilibon, Jerusalem, IL;
Orly Mouallem, Rechovot, IL;
Joel M. Van Gelder, Jerusalem, IL;
Joseph Y. Klein, Haifa, IL;
Yochai Basel, Rechovot, IL;
Anat Reizelman, Rechovot, IL;
Susanna Tchilibon, Jerusalem, IL;
Orly Mouallem, Rechovot, IL;
InSight Biopharmaceuticals Ltd., Rehovot, IL;
Abstract
Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these compounds, as defined in the specification, is characterized as having one or zero free-to-rotate bonds. Also disclosed are pharmaceutical compositions containing these rigidified compounds and uses thereof for modulating the activity of heparanase and hence in the treatment of heparanase-associated diseases and disorders, and uses thereof for modulating the activity of heparin-binding proteins and hence in the treatment of heparin-binding proteins-associated diseases and disorders as well as in the treatment of medical conditions that are at least partially treatable by rhodanine or a rhodanine analog.