The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2010
Filed:
Dec. 18, 2007
Pasit Phiasivongsa, Brentwood, CA (US);
Sanjeev G. Redkar, Hayward, CA (US);
Swarna Gamage, Mt Roskill, NZ;
Darby Brooke, Waterview, NZ;
William Denny, Pakuranga, NZ;
David J. Bearss, Cedar Hills, UT (US);
Hariprasad Vankayalapati, Draper, UT (US);
Pasit Phiasivongsa, Brentwood, CA (US);
Sanjeev G. Redkar, Hayward, CA (US);
Swarna Gamage, Mt Roskill, NZ;
Darby Brooke, Waterview, NZ;
William Denny, Pakuranga, NZ;
David J. Bearss, Cedar Hills, UT (US);
Hariprasad Vankayalapati, Draper, UT (US);
SuperGen, Inc., Dublin, CA (US);
Abstract
Quinoline derivatives, particularly 4-anilinoquinoline derivatives of formula (I), are provided: Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT 1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.