The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
Sep. 12, 2007
Applicants:
Jonathan Lebowitz, Whitefish Bay, WI (US);
John Maga, Whitefish Bay, WI (US);
Inventors:
Jonathan LeBowitz, Whitefish Bay, WI (US);
John Maga, Whitefish Bay, WI (US);
Assignee:
ZyStor Therapeutics, Inc., Milwaukee, WI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/26 (2006.01); C12N 15/09 (2006.01); C12P 21/00 (2006.01); C07H 21/04 (2006.01); A01N 37/18 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.