The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2010
Filed:
Jun. 05, 2007
Eberhard Ehlers, Hofheim, DE;
Heinrich Decker, Eppstein, DE;
Sebastian Rissom, Hofheim, DE;
Guido Seidel, Frankfurt am Main, DE;
Reiner Olliger, Bruchkobel, DE;
Eberhard Ehlers, Hofheim, DE;
Heinrich Decker, Eppstein, DE;
Sebastian Rissom, Hofheim, DE;
Guido Seidel, Frankfurt am Main, DE;
Reiner Olliger, Bruchkobel, DE;
Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, DE;
Abstract
The invention relates to a method for the enzymatic elimination of the N-acyl side chain from lipopeptides to form the corresponding nucleus, wherein the lipopeptide is prepared by fermentation, the lipopeptide being bound to the cells of the biomass, and the biomass is removed with the adhering lipopeptide, the biomass with the adhering lipopeptide is resuspended in an aqueous system, a suitable deacylase is added in dissolved or solid form to the suspension of the biomass, and the corresponding nucleus is formed, and the nucleus is optionally isolated and purified, wherein the lipopeptide obtained by fermentation is reacted after the end of the fermentation as cell-bound biomass without further purification directly with a deacylase, whereby the N-acyl chain linked via an amide linkage is eliminated.