The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2010
Filed:
Apr. 01, 2004
Patrick Y. LU, Rockville, MD (US);
Frank Y. Xie, Germantown, MD (US);
Martin C. Woodle, Bethesda, MD (US);
Yijia Liu, Gaithersburg, MD (US);
Quinn Q. Tang, Gaithersburg, MD (US);
Jun Xu, Germantown, MD (US);
Patrick Y. Lu, Rockville, MD (US);
Frank Y. Xie, Germantown, MD (US);
Martin C. Woodle, Bethesda, MD (US);
Yijia Liu, Gaithersburg, MD (US);
Quinn Q. Tang, Gaithersburg, MD (US);
Jun Xu, Germantown, MD (US);
Intradigm Corporation, Palo Alto, CA (US);
Abstract
The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.