The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Dec. 30, 2004
Mark Roth, Seattle, WA (US);
Andrew Berlin, San Jose, CA (US);
Selena Chan, Sunnyvale, CA (US);
Tae-woong Koo, Cupertino, CA (US);
Xing Su, Cupertino, CA (US);
Lei Sun, Santa Clara, CA (US);
Mark Roth, Seattle, WA (US);
Andrew Berlin, San Jose, CA (US);
Selena Chan, Sunnyvale, CA (US);
Tae-Woong Koo, Cupertino, CA (US);
Xing Su, Cupertino, CA (US);
Lei Sun, Santa Clara, CA (US);
Intel Corporation, Santa Clara, CA (US);
Abstract
Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.