The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2010
Filed:
Feb. 06, 2008
Anatoly A. Mazurov, Greenboro, NC (US);
Jozef Klucik, Rural Hall, NC (US);
Lan Miao, Advance, NC (US);
Angela S. Seamans, Jamestown, NC (US);
Teresa Youngpeter Phillips, Greensboro, NC (US);
Jeffrey Daniel Schmitt, Winston-Salem, NC (US);
Craig Harrison Miller, Winston-Salem, NC (US);
Anatoly A. Mazurov, Greenboro, NC (US);
Jozef Klucik, Rural Hall, NC (US);
Lan Miao, Advance, NC (US);
Angela S. Seamans, Jamestown, NC (US);
Teresa Youngpeter Phillips, Greensboro, NC (US);
Jeffrey Daniel Schmitt, Winston-Salem, NC (US);
Craig Harrison Miller, Winston-Salem, NC (US);
Targacept, Inc., Winston-Salem, NC (US);
Abstract
The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds, and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.