The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Dec. 26, 2006
Wei Liu, Lexington, MA (US);
Bradley A. Ozenberger, Olney, MD (US);
Leeying Wu, Lexington, MA (US);
Ching-hsiung Frederick Lo, Pennington, NJ (US);
Steven A. Haney, Concord, MA (US);
Hemchand Sookdeo, Natick, MA (US);
Jee Hyung Lee, Boston, MA (US);
Wei Liu, Lexington, MA (US);
Bradley A. Ozenberger, Olney, MD (US);
Leeying Wu, Lexington, MA (US);
Ching-Hsiung Frederick Lo, Pennington, NJ (US);
Steven A. Haney, Concord, MA (US);
Hemchand Sookdeo, Natick, MA (US);
Jee Hyung Lee, Boston, MA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), isolated nucleic acid molecules that encode these polypeptides, inhibitors, and methods related thereto. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention, as well as inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention. The invention further provides uses of HIPK4 and its inhibitors, e.g., mutants of HIPK4 lacking protein kinase activity, for modulation of apoptosis, as well as the prevention and treatment of neurological disorders and cancers.