The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Mar. 30, 2006
Paul S. Watson, Carrboro, NC (US);
James G. Douglass, Iii, Apex, NC (US);
Bob Suchozak, Newmarket, CA;
Subramanian Pandiaraju, Brampton, CA;
Craig E. Dixon, Whitby, CA;
Daniel Levin, Toronto, CA;
Paul S. Watson, Carrboro, NC (US);
James G. Douglass, III, Apex, NC (US);
Bob Suchozak, Newmarket, CA;
Subramanian Pandiaraju, Brampton, CA;
Craig E. Dixon, Whitby, CA;
Daniel Levin, Toronto, CA;
Inspire Pharmaceuticals, Inc., Durham, NC (US);
Abstract
The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.