The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Nov. 12, 2004
Jian-qiang Fan, Demarest, NJ (US);
Xiaoxiang Zhu, North Brunswick, NJ (US);
Kamlesh Sheth, North Brunswick, NJ (US);
Jian-Qiang Fan, Demarest, NJ (US);
Xiaoxiang Zhu, North Brunswick, NJ (US);
Kamlesh Sheth, North Brunswick, NJ (US);
Amicus Therapeutics, Inc., Cranbury, NJ (US);
Abstract
The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons. The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as 'active-site specific chaperones' for the mutant glucocerebrosidase associated with the disease.