The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Mar. 31, 2005
Takashi Kadowaki, Tokyo, JP;
Toshimasa Yamauchi, Tokyo, JP;
Shoko Kitajima, Tokyo, JP;
Yusuke Ito, Saitama, JP;
Takashi Kadowaki, Tokyo, JP;
Toshimasa Yamauchi, Tokyo, JP;
Shoko Kitajima, Tokyo, JP;
Yusuke Ito, Saitama, JP;
Nissan Chemical Industries, Ltd., Tokyo, JP;
Toudai TLO, Ltd, Tokyo, JP;
Abstract
The present invention provides adiponectin expression-inducing agents, and therapeutic agents using the same for obesity and obesity-related diseases such as cardiovascular diseases or metabolic diseases, as well as methods of searching for adiponectin expression-inducing agents. KLF9, which can bind to the 32-bp fragment of position −188 to position −157 from the adiponectin expression start site, was demonstrated to enhance adiponectin promoter activity. Therefore, the present invention uses KLF9 as an adiponectin expression-inducing agent, and suggests that KLF9 replenishment therapy is useful for preventing and/or treating obesity or obesity-related diseases including metabolic diseases such as insulin resistance and type II diabetes, and cardiovascular diseases.