The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Nov. 25, 2004
Shunichi Shiozawa, Nishi-ku, Kobe-shi, Hyogo, JP;
Kayo Osawa, Kobe, JP;
Nozomi Takami, Kobe, JP;
Akira Hashiramoto, Kobe, JP;
Yasushi Miura, Kobe, JP;
Shunichi Shiozawa, Nishi-ku, Kobe-shi, Hyogo, JP;
Kayo Osawa, Kobe, JP;
Nozomi Takami, Kobe, JP;
Akira Hashiramoto, Kobe, JP;
Yasushi Miura, Kobe, JP;
Other;
Abstract
Analysis is made on the DNA methylation of the region (including a promoter region) upstream from the translation initiation point of a rheumatoid arthritis-associated gene DR3 in human genome. As a result, it is found out that an allele-specific methylation occurs in a CpG sequence located about −380 to −180 bp upstream from translation initiation point (ATG) of the gene DR3. It is further found out that the CpG sequences downstream therefrom of the genes DR3 originating in healthy subjects are all in the unmethylated state, while methylated and unmethylated sequences are both observed in the genes DR3 originating in RA patients.