The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2010
Filed:
Sep. 06, 2001
Johan Gotthardt Olsen, Copenhagen, DK;
Anders Kadziola, Hellerup, DK;
Søren Weis Dahl, Rungsted Kyst, DK;
Connie Lauritzen, Rødovre, DK;
Sine Larsen, Hørsholm, DK;
John Pedersen, Nivå, DK;
Dusan Turk, Ljubljana, SI;
Marjetka Podobnik, Ljubljana-Polje, SI;
Igor Stern, Ljubljana, SI;
Johan Gotthardt Olsen, Copenhagen, DK;
Anders Kadziola, Hellerup, DK;
Søren Weis Dahl, Rungsted Kyst, DK;
Connie Lauritzen, Rødovre, DK;
Sine Larsen, Hørsholm, DK;
John Pedersen, Nivå, DK;
Dusan Turk, Ljubljana, SI;
Marjetka Podobnik, Ljubljana-Polje, SI;
Igor Stern, Ljubljana, SI;
Prozymex A/S, Horsholm, DK;
Abstract
The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present invention is a crystal of a dipeptidyl peptidase I (DPPI) and corresponding structural information obtained by X-ray crystallography from rat and human DPPI. In addition, this invention relates to methods for using structure co-ordinates of DDPI, mutants hereof and co-complexes, to design compounds that bind to the active site or accessory binding sites of DPPI and to design improved inhibitors of DPPI or homologues of the enzyme.