The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2010
Filed:
Mar. 30, 2005
Rene Daniel, Ambler, PA (US);
Anna Marie Skalka, Princeton, NJ (US);
Gary D. Kao, Wynnewood, PA (US);
Giuseppe Nunnari, Cantania, IT;
Roger J. Pomerantz, Chalfont, PA (US);
Rene Daniel, Ambler, PA (US);
Anna Marie Skalka, Princeton, NJ (US);
Gary D. Kao, Wynnewood, PA (US);
Giuseppe Nunnari, Cantania, IT;
Roger J. Pomerantz, Chalfont, PA (US);
Fox Chase Cancer Center, Philadelphia, PA (US);
Abstract
Cellular targets for anti-retroviral drug development are disclosed. The cellular targets comprise ATR kinase and its relevant substrates, based on the identification of the ATR kinase as required for the final step of retroviral DNA integration. Assays for identifying modulators of retroviral integration via the ATR kinase pathway are disclosed, as well as modulators identified by such assays. Pharmaceutical preparations and methods of their use in treating retroviral infection are also disclosed.