The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2010
Filed:
Aug. 20, 2008
David H. Beach, Huntington Bay, NY (US);
Douglas J. Demetrick, Northport, NY (US);
Manuel Serrano, Mill Neck, NY (US);
Gregory J. Hannon, Huntington, NY (US);
David H. Beach, Huntington Bay, NY (US);
Douglas J. Demetrick, Northport, NY (US);
Manuel Serrano, Mill Neck, NY (US);
Gregory J. Hannon, Huntington, NY (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Abstract
The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins ('CCR-proteins'). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. The present invention comprises antibodies directed to such CCR-proteins. The present invention is directed to a kit for detecting the level of cyclin-dependent kinase inhibitor p16 gene expression comprising antibodies directed to a p16 protein.