The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2010
Filed:
Mar. 10, 2006
Dalian Zhao, Fanwood, NJ (US);
Jean-francois Marcoux, St-Symphorien d'Ozon, FR;
David Boardman, Norristown, NJ (US);
Aquiles E. Leyes, Schwenksville, PA (US);
Dalian Zhao, Fanwood, NJ (US);
Jean-Francois Marcoux, St-Symphorien d'Ozon, FR;
David Boardman, Norristown, NJ (US);
Aquiles E. Leyes, Schwenksville, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Novel crystalline forms of two indole compounds connected to phenoxyalkylcarboxylic acid groups are selective PPAR gamma partial agonists that are useful in the treatment of type 2 diabetes, hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. The novel crystal forms include a crystalline free acid dihydrate and crystalline free acid anhydrate of one compound and several crystalline forms of the free acid and the sodium salt of the second compound. The invention also relates to pharmaceutical compositions comprising these novel crystal forms, processes to prepare the crystal forms and their pharmaceutical compositions, and uses of the crystal forms in the treatment of type 2 diabetes and other PPAR gamma modulated diseases.