The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2010
Filed:
Oct. 26, 2004
Axel Bouchon, Köln, DE;
Nicole Diedrichs, Velbert, DE;
Achim Hermann, Düseldorf, DE;
Klemens Lustig, Wuppertal, DE;
Heinrich Meier, Wuppertal, DE;
Josef Pernerstorfer, Hilden, DE;
Elke Reiβmüller, Wuppertal, DE;
Muneto Mogi, Tsukuba, JP;
Hiroshi Fujishima, Nara-ken, JP;
Masaomi Tajimi, Aichi-ken, JP;
Noriyuki Yamamoto, Osaka-fu, JP;
Axel Bouchon, Köln, DE;
Nicole Diedrichs, Velbert, DE;
Achim Hermann, Düseldorf, DE;
Klemens Lustig, Wuppertal, DE;
Heinrich Meier, Wuppertal, DE;
Josef Pernerstorfer, Hilden, DE;
Elke Reiβmüller, Wuppertal, DE;
Muneto Mogi, Tsukuba, JP;
Hiroshi Fujishima, Nara-ken, JP;
Masaomi Tajimi, Aichi-ken, JP;
Noriyuki Yamamoto, Osaka-fu, JP;
Bayer Schering Pharma Aktiengesellschaft, Berlin, DE;
Abstract
This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of the present invention has vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).