The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2010
Filed:
Apr. 08, 2005
Guojie Ho, Sudbury, MA (US);
Antoinette D. Paone, Lexington, MA (US);
Luciano Forni, La Louviere, BE;
Catherine DE Tollenaere, Louvain-la-Neuve, BE;
Brice Bonnet, Levallois-Perret, FR;
Christine Devijver, Brussels, BE;
Guojie Ho, Sudbury, MA (US);
Antoinette D. Paone, Lexington, MA (US);
Luciano Forni, La Louviere, BE;
Catherine De Tollenaere, Louvain-la-Neuve, BE;
Brice Bonnet, Levallois-Perret, FR;
Christine Devijver, Brussels, BE;
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.