The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2010
Filed:
Nov. 27, 2007
Avigdor Shafferman, Ness Ziona, IL;
Anat Zvi, Gedera, IL;
Naomi Ariel, Ness Ziona, IL;
John Fulkerson, Silver Spring, MD (US);
Ronggai Sun, Ellicott City, MD (US);
Rosemary Chang, Bethesda, MD (US);
Jerald C. Sadoff, Washington, DC (US);
Avigdor Shafferman, Ness Ziona, IL;
Anat Zvi, Gedera, IL;
Naomi Ariel, Ness Ziona, IL;
John Fulkerson, Silver Spring, MD (US);
Ronggai Sun, Ellicott City, MD (US);
Rosemary Chang, Bethesda, MD (US);
Jerald C. Sadoff, Washington, DC (US);
Aeras Global TB Vaccine Foundation, Rockville, MD (US);
Abstract
A vaccine against(Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.