The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
Nov. 26, 2003
Pingyu Zhong, Mountain View, CA (US);
Peizhi Luo, Sunnyvale, CA (US);
Kevin C. Wang, San Francisco, CA (US);
Mark Hsieh, San Francisco, CA (US);
Yan LI, San Jose, CA (US);
Pingyu Zhong, Mountain View, CA (US);
Peizhi Luo, Sunnyvale, CA (US);
Kevin C. Wang, San Francisco, CA (US);
Mark Hsieh, San Francisco, CA (US);
Yan Li, San Jose, CA (US);
Abmaxis, Inc., Mountain View, CA (US);
Abstract
Methods are provided for designing and selecting antibodies against human antigens with high affinity and specificity in silico and in vitro. In some particular embodiments, methods are provided for designing and selecting humanized or fully human antibodies against vascular endothelial growth factor (VEGF) with high affinity and specificity. In another aspect of the invention, monoclonal antibodies against VEGF are provided. In particular, humanized or human anti-VEGF monoclonal antibodies are provided with ability to bind to human VEGF with high affinity, inhibit VEGF-induced proliferation of endothelial cells in vitro and inhibit VEGF-induced angiogenesis in vivo. These antibodies and their derivative can be used in a wide variety of applications such as diagnosis, prevention, and treatment of diseases such as cancer, AMD, diabetic retinopathy, and other diseases derived from pathological angiogenesis.