The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 23, 2010
Filed:
May. 02, 1995
Mariagrazia Pizza, Siena, IT;
Antonello Covacci, Siena, IT;
Rino Rappuoli, Castelnuovo Berardenga, IT;
Luciano Nencioni, Poggibonsi, IT;
Mariagrazia Pizza, Siena, IT;
Antonello Covacci, Siena, IT;
Rino Rappuoli, Castelnuovo Berardenga, IT;
Luciano Nencioni, Poggibonsi, IT;
Novartis AG, Basel, CH;
Abstract
New pertussis toxin (PT) mutants are described being immunologically active and having reduced or no toxicity, characterized in that at least one of the amino acid residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly44, Thr53 and Gly80 of subunit S1 amino acid sequence is deleted and substituted by a different amino acid residue selected in the group of natural amino acids;strains capable of providing and secreting said PT mutants and means and methods for obtaining them are also described. Thestrains and the PT mutants produced by them are particularly suitable for the preparation of effective cellular and acellular antipertussis vaccines.