The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2009
Filed:
Apr. 11, 2005
Rebecca L. Rich, Salt Lake City, UT (US);
Bernd Kriekemeyer, Ulm, DE;
Rick T. Owens, Stewartsville, NJ (US);
Magnus Hook, Houston, TX (US);
Barbara E. Murray, Houston, TX (US);
Sreedhar R. Nallapareddy, Houston, TX (US);
George M. Weinstock, Houston, TX (US);
Rebecca L. Rich, Salt Lake City, UT (US);
Bernd Kriekemeyer, Ulm, DE;
Rick T. Owens, Stewartsville, NJ (US);
Magnus Hook, Houston, TX (US);
Barbara E. Murray, Houston, TX (US);
Sreedhar R. Nallapareddy, Houston, TX (US);
George M. Weinstock, Houston, TX (US);
The Texas A & M University System, College Station, TX (US);
Board of Regents of the University of Texas System, Austin, TX (US);
Abstract
A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate.