The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2009
Filed:
Jun. 09, 2008
Thomas Cleary, Florence, SC (US);
Yaohui Ji, Florence, SC (US);
Gary R. Lee, Belmont, CA (US);
Thimma Rawalpally, Florence, SC (US);
Keshab Sarma, Sunnyvale, CA (US);
Thomas Cleary, Florence, SC (US);
Yaohui Ji, Florence, SC (US);
Gary R. Lee, Belmont, CA (US);
Thimma Rawalpally, Florence, SC (US);
Keshab Sarma, Sunnyvale, CA (US);
Hoffmann-La Roche Inc., Nutley, NJ (US);
Roche Palo Alto LLC, Palo Alto, CA (US);
Abstract
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.