The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2009
Filed:
Nov. 22, 2000
William J. Boyle, Moorpark, CA (US);
David L. Lacey, Thousand Oaks, CA (US);
Frank J. Calzone, Westlake Village, CA (US);
Ming-shi Chang, Newbury Park, CA (US);
William J. Boyle, Moorpark, CA (US);
David L. Lacey, Thousand Oaks, CA (US);
Frank J. Calzone, Westlake Village, CA (US);
Ming-Shi Chang, Newbury Park, CA (US);
Amgen, Inc., Thousand Oaks, CA (US);
Abstract
The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.