The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2009
Filed:
Dec. 28, 2006
Richard M. Ivey, Parkton, MD (US);
Thomas M. Gentle, Jr., Red Lion, PA (US);
Richard L. Moore, Glenville, PA (US);
Michael L. Towns, Timonium, MD (US);
Nicholas Bachur, Jr., Monkton, MD (US);
Robert W. Rosenstein, Ellicott City, MD (US);
James G. Nadeau, Ellicott City, MD (US);
Paul E. Goldenbaum, Hampstead, MD (US);
Song Shi, Reisterstown, MD (US);
Donald Copertino, Catonsville, MD (US);
James Garrett, Baltimore, MD (US);
Gregory Tice, Lutherville, MD (US);
Gary Siuzdak, San Diego, CA (US);
Elizabeth Want, San Diego, CA (US);
Zhouxin Shen, San Diego, CA (US);
Richard M. Ivey, Parkton, MD (US);
Thomas M. Gentle, Jr., Red Lion, PA (US);
Richard L. Moore, Glenville, PA (US);
Michael L. Towns, Timonium, MD (US);
Nicholas Bachur, Jr., Monkton, MD (US);
Robert W. Rosenstein, Ellicott City, MD (US);
James G. Nadeau, Ellicott City, MD (US);
Paul E. Goldenbaum, Hampstead, MD (US);
Song Shi, Reisterstown, MD (US);
Donald Copertino, Catonsville, MD (US);
James Garrett, Baltimore, MD (US);
Gregory Tice, Lutherville, MD (US);
Gary Siuzdak, San Diego, CA (US);
Elizabeth Want, San Diego, CA (US);
Zhouxin Shen, San Diego, CA (US);
Becton, Dickinson and Company, Franklin Lake, NJ (US);
Abstract
Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.