The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2009
Filed:
Jan. 28, 2003
Yuanchao LI, Shanghai, CN;
Jianping Zuo, Shanghai, CN;
Fan Zhang, Shanghai, CN;
RU Zhou, Shanghai, CN;
Jian Ding, Shanghai, CN;
Yuanchao Li, Shanghai, CN;
Jianping Zuo, Shanghai, CN;
Fan Zhang, Shanghai, CN;
Ru Zhou, Shanghai, CN;
Jian Ding, Shanghai, CN;
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, CN;
Shanghai Pharmaceutical (Group) Co., Ltd., Shanghai, CN;
Abstract
Triptolide derivatives of Formula (I), their pharmaceutically acceptable salts and optical isomers, Formula (I): wherein, C5 and C6 are connect with each other by a C-C single bond or double bond; when C5 and C6 are connected with C-C single bond, X and Y represent independently hydrogen, oxygen, hydroxyl, halogen, lower alkyl-oxy, lower alkyl-amino, mercapto, lower alkyl-thio, the group of formula —OCOR, —OSOOR or —OPO(OH), each of which is attached to C5 and C6, R represents —(CH)nCONa, —(CO)nCOK, or —(CH)nCH, wherein n=1-6; Z represents hydrogen, oxygen, hydroxyl, halogen, lower alkyl-oxy, lower alkyl-amino, mercapto, lower alkyl-thio, the group of formula -OCOR, -OSOOR or —OPO(OH)2, each of which is linked at C14-position, R represents —(CH2)nCO2Na, —(CO2)nCO2K, or —(CH)nCH, wherein n=1-6; wherein, the'______' linked with X, Y, and Z represents the stereochemistry orientations '' or “” , but X and Y cannot both be hydrogen atom at the same time, methods for preparing the triptolides and their use as antiphiogistic agent, immunosuppressive agent or therapeutic agent for other related diseases.