The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2009
Filed:
Dec. 06, 2004
Rachel Schneerson, Bethesda, MD (US);
Joanna Kubler-kielb, Rockville, MD (US);
Fathy Majadly, Frederick, MD (US);
Stephen H. Leppla, Bethesda, MD (US);
John B. Robbins, Bethesda, MD (US);
Darrell T. Liu, Bethesda, MD (US);
Joseph Shiloach, Rockville, MD (US);
Rachel Schneerson, Bethesda, MD (US);
Joanna Kubler-Kielb, Rockville, MD (US);
Fathy Majadly, Frederick, MD (US);
Stephen H. Leppla, Bethesda, MD (US);
John B. Robbins, Bethesda, MD (US);
Darrell T. Liu, Bethesda, MD (US);
Joseph Shiloach, Rockville, MD (US);
Abstract
Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazino-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.