The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2009
Filed:
Feb. 16, 2006
Alessio Fasano, West Friendship, MD (US);
Ruiliang LU, Baltimore, MD (US);
Stefanie N. Vogel, Columbia, MD (US);
Julie Brownley, Towson, MD (US);
Karen Lammers, Baltimore, MD (US);
Alessio Fasano, West Friendship, MD (US);
Ruiliang Lu, Baltimore, MD (US);
Stefanie N. Vogel, Columbia, MD (US);
Julie Brownley, Towson, MD (US);
Karen Lammers, Baltimore, MD (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Abstract
CXCR3 is identified as a physiological receptor for Gliadin. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin which function as inhibitors of CXCR3 signaling can be determined. Methods for treating diseases relating to gluten and/or autoimmunity by targeting CXCR3 are provided. Such diseases include celiac disease, gluten sensitivity, gluten allergy, rheumatoid arthritis, multiple sclerosis, immune-mediated or type 1 diabetes mellitus, inflammatory bowel diseases, systemic lupus erythematosus, psoriasis, scleroderma, and autoimmune thyroid diseases.