The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2009
Filed:
May. 22, 2006
Kathryn Rene Bracken, Swampscott, MA (US);
Simon Bushell, Boston, MA (US);
Karl Dean, Marlborough, MA (US);
Charles Francavilla, Fremont, CA (US);
Rakesh K. Jain, Fremont, CA (US);
Kwangho Lee, Lexington, MA (US);
Mohindra Seepersaud, Belmont, MA (US);
Lei Shu, Woburn, MA (US);
Arathi Sundaram, Fremont, CA (US);
Zhengyu Yuan, Palo Alto, CA (US);
Kathryn Rene Bracken, Swampscott, MA (US);
Simon Bushell, Boston, MA (US);
Karl Dean, Marlborough, MA (US);
Charles Francavilla, Fremont, CA (US);
Rakesh K. Jain, Fremont, CA (US);
Kwangho Lee, Lexington, MA (US);
Mohindra Seepersaud, Belmont, MA (US);
Lei Shu, Woburn, MA (US);
Arathi Sundaram, Fremont, CA (US);
Zhengyu Yuan, Palo Alto, CA (US);
Novartis AG, Basel, CH;
Vicuron Pharmaceuticals, Inc., Vienna, AT;
Abstract
Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.