The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2009
Filed:
Sep. 15, 2003
Christophe DE Romeuf, Lille, FR;
Christine Gaucher, Sequedin, FR;
Arnaud Clacet, Gondecourt, FR;
Frédéric Dhainaut, Boissy-le-Sec, FR;
Dominique Bourel, La Madeleine, FR;
Nicolas Bihoreau, Orsay, FR;
Emmanuel Nony, Antony, FR;
Christophe de Romeuf, Lille, FR;
Christine Gaucher, Sequedin, FR;
Arnaud Clacet, Gondecourt, FR;
Frédéric Dhainaut, Boissy-le-Sec, FR;
Dominique Bourel, La Madeleine, FR;
Nicolas Bihoreau, Orsay, FR;
Emmanuel Nony, Antony, FR;
Abstract
The invention relates to a method of measuring the activation of an effector cell belonging to the immune system, which may or may not be transformed, using a monoclonal (AcMo) or polyclonal antibody. The invention is characterised in that it consists in: bringing into contact (i) CD16 receptor-expressing cells in a reaction medium in the presence of the antibody and (ii) the antigen of said antibody, and measuring the quantity of at least one cytokine produced by the CD16 receptor-expressing cell. The invention also relates to the selection of an antibody capable of inducing the expression of cytokines and interleukins, such as IFN? or IL2 which are intended for the treatment of autoimmune and inflammatory diseases, cancers and infections by pathogens.