The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2009
Filed:
May. 05, 2006
Bernd Dorken, Berlin, DE;
Gert Riethmuller, Munich, DE;
Peter Kufer, Moosburg, DE;
Ralf Lutterbuse, Munich, DE;
Ralf Bargou, Berlin, DE;
Anja Loffler, Finowfurt/Eichhorst, DE;
Bernd Dorken, Berlin, DE;
Gert Riethmuller, Munich, DE;
Peter Kufer, Moosburg, DE;
Ralf Lutterbuse, Munich, DE;
Ralf Bargou, Berlin, DE;
Anja Loffler, Finowfurt/Eichhorst, DE;
Micromet AG, Munich, DE;
Abstract
Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above-described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described. In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.