The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 11, 2009
Filed:
Sep. 16, 2003
Se-jin Lee, Baltimore, MD (US);
Alexandra C. Mcpherron, Baltimore, MD (US);
Daniel S. Greenspan, Madison, WI (US);
William N. Pappano, Columbia, MD (US);
Neil Wolfman, Dover, MA (US);
Kathy Tomkinson, Cambridge, MA (US);
Se-Jin Lee, Baltimore, MD (US);
Alexandra C. McPherron, Baltimore, MD (US);
Daniel S. Greenspan, Madison, WI (US);
William N. Pappano, Columbia, MD (US);
Neil Wolfman, Dover, MA (US);
Kathy Tomkinson, Cambridge, MA (US);
The Johns Hopkins University School of Medicine, Baltimore, MD (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Wyeth, Madison, NJ (US);
Abstract
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.