The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2009
Filed:
Jul. 14, 2006
Jeffry D. Watkins, Encinitas, CA (US);
William D. Huse, Del Mar, CA (US);
Ying Tang, San Diego, CA (US);
Daniel Broek, Los Angeles, CA (US);
Peter Brooks, Carmel, NY (US);
Jeffry D. Watkins, Encinitas, CA (US);
William D. Huse, Del Mar, CA (US);
Ying Tang, San Diego, CA (US);
Daniel Broek, Los Angeles, CA (US);
Peter Brooks, Carmel, NY (US);
Cell-Matrix, Inc., Bethesda, MD (US);
Abstract
The invention provides an antibody, or functional fragment thereof, a grafted antibody, or functional fragment thereof, comprising one or more complementarity determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis.