The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2009
Filed:
Apr. 14, 2005
Leonid Beigelman, Longmont, CO (US);
Jasenka Matulic-adamic, Boulder, CO (US);
Alexander Karpeisky, Layfayette, CO (US);
Peter Haeberli, Berthoud, CO (US);
David Sweedler, Louisville, CO (US);
Mark Reynolds, Pleasanton, CA (US);
Nilabh Chaudhary, Superior, CO (US);
John Min, Longmont, CO (US);
Leonid Beigelman, Longmont, CO (US);
Jasenka Matulic-Adamic, Boulder, CO (US);
Alexander Karpeisky, Layfayette, CO (US);
Peter Haeberli, Berthoud, CO (US);
David Sweedler, Louisville, CO (US);
Mark Reynolds, Pleasanton, CA (US);
Nilabh Chaudhary, Superior, CO (US);
John Min, Longmont, CO (US);
Sirna Therapeutics, Inc., San Francisco, CA (US);
Abstract
This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAS, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.