The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2009
Filed:
Nov. 21, 2003
Robert W. Curley, Jr., Columbus, OH (US);
Serena M. Mershon, St. Louis, MO (US);
Derek W. Barnett, Columbus, OH (US);
Margaret Clagett-dame, Deerfield, WI (US);
Jason S. Chapman, Madison, WI (US);
Robert W. Curley, Jr., Columbus, OH (US);
Serena M. Mershon, St. Louis, MO (US);
Derek W. Barnett, Columbus, OH (US);
Margaret Clagett-Dame, Deerfield, WI (US);
Jason S. Chapman, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.