The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2009
Filed:
Nov. 01, 2006
Linda K. Joliffe, Belle Mead, NJ (US);
Robert A. Zivin, Lawrenceville, NJ (US);
Virginia L. Pulito, Flemington, NJ (US);
Linda K. Joliffe, Belle Mead, NJ (US);
Robert A. Zivin, Lawrenceville, NJ (US);
Virginia L. Pulito, Flemington, NJ (US);
Centocor, Inc., Malvern, PA (US);
Abstract
The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants and are thus useful in the treatment and prophylaxis of human thrombotic disease. The invention also provides methods of making the CFR-grafted antibodies and pharmaceutical compositions for the attenuation or prevention of coagulation.