The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2009
Filed:
Jun. 02, 2004
Gerald Raul Kovacs, Potomac, MD (US);
Xiaoyan MO, Boxborough, MA (US);
Nikolaos Vasilakis, Galveston, TX (US);
Sangeeta Bhargava, Potomac, MD (US);
Timothy Joseph Zamb, Nyack, NY (US);
Stephen Alexander Udem, New York, NY (US);
Gerald Raul Kovacs, Potomac, MD (US);
Xiaoyan Mo, Boxborough, MA (US);
Nikolaos Vasilakis, Galveston, TX (US);
Sangeeta Bhargava, Potomac, MD (US);
Timothy Joseph Zamb, Nyack, NY (US);
Stephen Alexander Udem, New York, NY (US);
Wyeth Holdings Corporation, Madison, NJ (US);
Abstract
Self-propagating, fusogenic blebs are produced from cells infected with a population of Venezuelan Equine Encephalitis virus replicon particles (VRP). The self-propagating, fusogenic nature of the blebs is derived from expression of heterologous genes encoding viral fusion proteins that are incorporated into the replication defective replicon particles. The resulting blebs can be harvested from supernatants of cells displaying severe cytopathic effects. The blebs are used to make immunogenic compositions and devise methods of immunizing mammals against paramyxoviruses such as parainfluenza virus type 3.