The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2009
Filed:
Apr. 29, 2003
Applicants:
Theodore W. Randolph, Niwot, CO (US);
John F. Carpenter, Littleton, CO (US);
Richard J. St. John, San Francisco, CA (US);
Jonathan N. Webb, Zionsville, IN (US);
Inventors:
Theodore W. Randolph, Niwot, CO (US);
John F. Carpenter, Littleton, CO (US);
Richard J. St. John, San Francisco, CA (US);
Jonathan N. Webb, Zionsville, IN (US);
Assignee:
Barofold, Inc., Boulder, CO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/02 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, 'stepped' depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.